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Favipiravir

is a Star Product of
LGM Pharma

LGM Pharma


General information
Registration name: Favipiravir
Other product names:
6-Fluoro-3-hydroxypyrazine-2-carboxamide
Pyrazinecarboxamide
T-705
5-Fluoro-2-oxo-1H-pyrazine-3-carboxamide
Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-
6-Fluoro-3,4-dihydro-3-oxo-pyrazinecarboxamide
 
CAS number 259793-96-9 Structure
EINECS:
Formula: C5H4FN3O2

Detailed information on the Star Product
Mode of Action:
The mechanism of action of favipiravir is novel compared to existing influenza antivirals that primarily prevent entry and exit of the virus from cells. The active favipiravir-RTP selectively inhibits RNA polymerase and prevents replication of the viral genome.18 There are several hypotheses as to how favipiravir-RTP interacts with RdRp. Some studies have shown that when favipiravir-RTP is incorporated into a nascent RNA strand, it prevents RNA strand elongation and viral proliferation. Studies have also found that the presence of purine analogs can reduce favipiravir’s antiviral activity, suggesting competition between favipiravir-RTP and purine nucleosides for RdRp binding.
Although originally developed to target influenza, the RdRp catalytic domain is expected to be similar for other RNA viruses. This conserved RdRp catalytic domain contributes to favipiravir's broad-spectrum coverage.

Information on the supplier

LGM Pharma

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